Malignant neoplasms of oral mucosa cysts of oral mucosa describe the characteristic or unique clinical features of the most common andor important diseases of the oral mucosa. Multiple lymphoepithelial cysts from oral mucosa of a healthy. Benign lymphoepithelial cyst blc, also known as branchial cyst, is an infrequent lesion usually occurs in the parotid gland or the lateral cervical area including lymph nodes. Parotid lymphoepithelial cysts in human immunodeficiency virus. Lesions arising from the salivary gland tissue included within the lymph nodes a. Benign lymphoepithelial lesion is most likely to occur in adults around 50 years of age. Bhaskar, lieutenant colonel, dc, usa united states army institute of dental research, walter reed army medical center t e he lymphoepithelial cyst of the oral cavity is rare, and a series of these lesions has never been described in the literature. Branchial cleft cystlike formation sometimes seen in hashimotos thyroiditis 7. A guide to clinical differential diagnosis of oral mucosal lesions.
Unusual coexistence of oral lymphoepithelial cyst and. Lymphoepithelial cyst lec is a rare developmental cystic lesion of the oral cavity with various histogenetic implications. The cyst appears encapsulated by the surrounding lymphoid tissue see figure 3. As with all true cysts, it has an epithelial lining. Various theories on its pathogenesis have been proposed, of which two are most widely accepted. Oral lymphoepithelial cyst olec is a rare and benign lesion of. A few case reports have been published of lec in the tonsillar region.
This case report describes the pertinent characteristics of this entity, involving the floor of the mouth in a 4 yearold boy. Lymphoepithelial carcinoma, which is a variant of undifferentiated carcinoma, is distinguished from small cell and large cell undifferentiated carcinoma by its association with benign lymphoepithelial lesions. Lymphoepithelial carcinoma lec is a rare subtype of oral carcinoma. Sep 18, 2016 lymphoepithelial cyst lec, otherwise known as the branchial cleft cyst, is the most commonly encountered congenital neck pathology in the lateral part of the neck. Tufts university school of dental medicine twentyone cases of biopsied lesions diagnosed as lymphoepithelial cyst have been reported. Mikuliczs disease benign lymphoepithelial lesion or sialolymphadenitis.
We report a case of a lymphoepithelial carcinoma developing in a minor salivary gland of the oral cavity in a 69yearold woman. There is a preponderance of this disease in those who suffer from hiv infection. They are soft on palpation, less than 1 cm in size, and the patient usually reports a noticeable, painless swelling. Benign lymphoepithelial lesions radiology reference article. Oral lymphoepithelial cyst olec is an uncommon lesion that develops in oral lymphoid tissue. It is a lesion that develops within the oral lymphoid tissue, microscopically similar to the branchial cleft cyst cervical lymphoepithelial cyst, but much smaller in size 1, 2. Methods samples were retrospectively retrieved from five ora. Background analyze the clinical, demographic, histopathological, and immunohistochemical features of oral lymphoepithelial cyst olec.
Dec, 2018 oral lymphoepithelial cyst olc is a rare benign tumor that forms in the oral cavity mouth. This case report describes the pertinent characteristics of this entity, involving the floor of. Benign lymphoepithelial lesions refer specifically to a histopathological finding that is nonspecific and seen in the context of lymphoepithelial sialadenitis typical of sjogren syndrome and hivassociated salivary gland disease 5. S, senior lecturer, department of oral medicine and radiology, kusum devi sunderlal dugar jain dental college and hospital, kolkata, west bengal, india. It is characterized by insidious swelling of one or several salivary and lacrimal glands fig. Lymphoepithelial cysts histologically similar to branchial cleft cysts of the lateral neck have been described at various sites, including the oral cavity,9 parotid gland,10 parathyroid glands,11 and pancreas.
Metwaly h, cheng j, idayonemochi h, ohshiro k, jen ky, liu ar, saku t. Aug 31, 2017 the topic benign lymphoepithelial cyst of oral cavity you are seeking is a synonym, or alternative name, or is closely related to the medical condition oral lymphoepithelial cyst. The patients ranged in age from 15 to 65 years, with an average age of 36. Coexistence of lymphoepithelial and epidermoid cysts on. Pdf the oral lymphoepithelial cyst is an uncommon lesion in children with rather distinct clinical features. Lymphoepithelial cyst definition of lymphoepithelial. Lymphoepithelial socalled branchial cysts are most often found in the lateral. A 22yearold patient presented a nodular lesion, yellowish, with a softened consistency, measuring. Oral pathology is a visual specialty, and clinical. Clinicopathological and immunohistochemical features of the. Single or multiple cysts in the lymph node benign lymphoepithelial cyst.
Review and case report article pdf available in journal of oral and maxillofacial pathology 224. Pdf lymphoepithelial cyst of tonsil semantic scholar. The coexistence of lymphoepithelial and epidermoid cysts in the oral cavity is extremely rare. The lateralventral tongue and floor of the mouth are common locations for this lesion. Benign lymphoepithelial cyst of oral cavity dovemed. A guide to clinical differential diagnosis of oral mucosal lesions continuing education brought to you by. Lymphoepithelial carcinoma of the parotid glands and its. Oral lec is a pathologic entity with discrete clinical presentation that is, however, commonly misdiagnosed in clinical practice as other, mostly benign, entities. This is a report of a lymphoepithelial cyst involving the submandibular salivary gland and its management. Histopathology of the lymphoepithelial cyst of the pancreas revealed squamous epithelial lining with no malignant features. It is a lesion that develops within the oral lymphoid tissue, microscopically similar to the branchial cleft cyst cervical lymphoepithelial cyst, but much smaller in size1, 2. Lesion primarily of lymphoid tissue but incidentally involving salivary gland a. The cyst is formed by dilation of the epithelial crypt normally present in lymphoid tissue, producing a cyst lined by stratified squamous epithelium.
The source of infection and treatment options are summarized. It usually occurs in adults with mean age around the. The patient was referred for endoscopic ultrasound and fine needle aspiration eusfna which revealed a hypoechoic, heterogeneous, pancreatic cystic mass in the region of the tail of the pancreas, measuring 95. The oral lymphoepithelial cyst lec is an uncommon developmental lesion usually discovered as an inci dental finding during a routine dental examination. Diagnosis and treatment of oral lymphoepithelial cyst. Gingival cyst of adult lymphoepithelial cyst epidermoiddermoid cyst thyroglossal tract cyst squamous cell carcinoma verrucous carcinoma lymphoma metastatic carcinoma melanoma sarcoma. Lymphoepithelial cyst definition of lymphoepithelial cyst. As with cervical branchial cysts, the therapeutic option in oral lecs is total excision. Another report from the journal of clinical experimental dentistry mentions 26 oral lymphoepithelial cysts, all less than 2 cm in size range. Oral lymphoepithelial cysts olc, also known as intraoral lymphoepithelial cysts lec or tonsillar crypt cysts, usually appear as a white or slightly yellow submucosal nodule.
Lymphoepithelial cyst of the oral cavity is a rare cystic lesion that presents as an asymptomatic, wellcircumscribed, yellowish small submucosal nodule covered by. Tani, lambert skoog, in comprehensive cytopathology third edition, 2008. The mainstay in the treatment of a lymphoepithelial cyst remains the surgical approach, which includes complete enucleation of the cyst along with total excision of the involved salivary gland. Surgery was performed due to this unilateral tonsillar mass, which was excised together with. In the present report, lymphoepithelial cyst of parotid was diagnosed in a middle aged immunocompetent patient, along with chronic otitis media. Clinicopathological and immunohistochemical features of. The are few reports in the literature of oral lymphoepithelial cysts, with isolated cases or short seri. Perform a stepbystep clinical differential diagnosis, using the decision tree, for patients with oral mucosal lesions. It is generally observed in young men, who are in their 4th decade of life no risk factors have been identified for oral lymphoepithelial cyst. Lymphoepithelial cysts of parotid are known to occur in hiv patients. Oral lymphoepithelial cyst olec is a rare and benign lesion of the oral cavity, corresponding to 0.
Oral lymphoepithelial cyst med oral patol oral cir bucal. Figure 1 from oral lymphoepithelial cyst in a young child. Vascular endothelial cell participation in formation of lymphoepithelial lesions epimyoepithelial islands in lymphoepithelial sialadenitis benign lymphoepithelial lesion. Ce 110 a guide to clinical differential diagnosis of. The border was poorly demarcated and was abutting the spleen. The posterior part of the oral cavity and the neighbor. The condition may result in decreased secretion from the glands, causing xerostomia. The incidence of hivassociated salivary gland disease is 3 to 10% among hiv infected patients, but the incidence may be influenced by the availability of anti. Lymphoepithelial cyst, also called branquial cyst, is a lesion in the oral cavity with rare incidence. Jul 20, 2017 the lymphoepithelial cyst in oral cavity is painless. Lymphoepithelial cysts of the oral cavity report of twentyfour cases surindar n. One such interaction of epithelium and lymphoid tissue may result in lymphoepithelial lesions in the oral cavity.
Ce 110 a guide to clinical differential diagnosis of oral. Thus, the coexistence of an oral lymphoepithelial cyst and benign migratory glossitis is probably an uncommon association between these diseases. Oral lymphoepithelial cyst olc is a rare benign tumor that forms in the oral cavity mouth. The aim of the present study was to report a clinical case of olec in the tongue. Dec 24, 2011 oral lymphoepithelial cyst presents as a movable, painless submucosal nodule with a yellow or yellowwhite discoloration. Pdf benign lymphoepithelial cyst blc, also known as branchial cyst, is an infrequent lesion usually occurs in the parotid gland or the lateral. In contrast, knapp suggested that these cysts in the oral cavity, more properly described as pseudocysts, derive from.
Lymphoepithelial cyst in jugal mucosa odontologia virtual. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. This has also been called salivary diffuse infiltrative lymphocytosis syndrome. Lymphoepithelial cysts of the thyroid gland archives of.
Case report lymphoepithelial cyst in the palatine tonsil. Unusual coexistence of oral lymphoepithelial cyst and benign. Lymphoepithelial cysts of the oral mucosa john giunta, d. When the lymphoepithelial cyst is found in the lateral neck region, it is called as branchial cleft cyst. Well circumscribed tan enlargement on the left posterior lateral border of the tongue.
Abstract a rare case of the oral lymphoepithelial cyst in the ventral surface of the tongue is reported. Only one case of lymphoepithelial cyst associated with two epidermoid cysts on the floor of the mouth has been reported in the literature and the present report describes a second case where a lymphoepithelial cyst coexisted with an epidermoid cyst on. Lymphoepithelial carcinoma of the minor salivary gland. The oral lymphoepithelial cyst is an uncommon lesion in children with rather distinct clinical features. Thus, the coexistence of an oral lymphoepithelial cyst and benign migratory glossitis is probably. Lymphoepithelial cysts of the oral mucosa sciencedirect. Introduction the lymphoepithelial cyst lec is a dysontogenic benign cyst originated from the epithelial remnant retained in lymphoid tissues during the embryogenesis, although it might also be related to branchial cleft epithelium 1,2. Benign lymphoepithelial lesion is a type of benign enlargement of the parotid andor lacrimal glands. This 64yearold male patient came to oral mucosal disease clinic in the dental department of far.
The oral lymphoepithelial cyst lec is a rare developmental lesion usually discovered as an incidental finding during a routine dental examination. The oral lymphoepithelial cyst is a rare, asymptomatic lesion with small. Primary lymphoepithelial like carcinoma of salivary glands. Primary lymphoepitheliallike carcinoma of the parotid.
Lymphoepithelial cyst is an uncommon lesion of the oral cavity. Lymphoepithelial lesions of salivary glands were first described by godwin in 1952. For instance, in a study of 120 patients with oral lymphoepithelial cysts, 50% were found on the tongue and 38. Branchial structures which develop at the 3rd to 7th weeks of life consist of the mesodermal arches and external clefts and the internal pounces separating these two structures 2. Although the origin of these lesions is unclear, their etiopathogenesis is distinct. The term lymphoepithelial was first recommended by bhaskar and bernier 2 in their report on 468 cases of branchial cysts of the neck. The present study offers the largest sample of olec for which clinical, demographic, histopathological, and immunohistochemical features were evaluated. The lymphoepithelial cyst in oral cavity is painless. There is a predilection for gender with 6080% being female. Oral lymphoepithelial cyst registered dental hygienist rdh. Oral lymphoepithelial cyst registered dental hygienist. Lymphoepithelial carcinoma definition of lymphoepithelial. Lymphoepithelial cyst of the submandibular gland europe pmc. Lecs may develop wherever normal or accessory lymphoid tissue exists.
Parotid lymphoepithelial cysts in human immunodeficiency. Diagnosis of oral lymphoepithelial cyst can be made by taking into consideration following criteria. Soon it was followed by the first case report of an oral lymphoepithelial cyst by gold and lewittown in 1962 1. This article focuses on the findings in the latter condition. A 66yearold woman presented to the ent clinic due to difficulty in swallowing persisting for approximately 1 year. Introduction the lymphoepithelial cyst lec is a dysontogenic benign cyst originated from the epithelial remnant retained in lymphoid tissues during the embryogenesis, although it. Bullous pemphigoid associated with a lymphoepithelial cyst. The oral lymphoepithelial cyst is composed of a cystic cavity. The tissue interactions between epithelium and mesenchyme are few of the events which result in pathological processes. These 26 oral lymphoepithelial cysts occur in 14 women and 11 men one 32yearold female patient with two identical lymphoepithelial cysts located at the bilateral posterior lateral borders of the tongue. The swelling can be asymptomatic, but mild pain can also be associated.
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